Association between hormone replacement therapy use and breast cancer risk varies
It is not known whether Manning, who has not started hormone therapy, will be allowed the medication while incarcerated. Manning was sentenced this week to 35 years in military prison for giving classified documents to the anti-secrecy group WikiLeaks. JoAnne Keatley, the director of the Center of Excellence for Transgendered Health at the University of California at San Francisco, calls the medication very expensive. It can run about $400 a month for those without coverage or whose insurance wont cover it. The hormones may come in pill or injectable form. Its a legitimate medical treatment that [patients] need access to, and being without it can lead to negative health outcomes including suicide, Keatley said. However, HRT has its limits which is where reconstructive surgery can come into play.
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Can hormone therapy help protect the brain?
A greater than 20% increased risk in breast cancer was associated with HRT use among white women and Hispanic women, but not black women. HRT use was more strongly associated with breast cancer risk in women with low or normal BMI but no association was observed among women with a high BMI. In addition, women with denser breasts had an increased likelihood of breast cancer among those who reported HRT use as well. The authors went on to investigate the combined effect of BMI and breast density because the two are correlated. They found a statistically significant interaction between breast density and HRT independent of BMI and identified high and low risk subgroups: HRT use was not associated with breast cancer for women with high BMI with low breast density whereas HRT use was associated with a statistically significant higher risk of breast cancer for women with low or normal BMI and high breast density.
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October 27, 2012 at 16:51 | Report abuse | Reply MKM Thanks for your thoughtful and well-informed approach to this issue, DrJohn. It was astounding how many physicians immediaetly adopted the media conclusions on HRT after the WHI study without ever actually reading the journal article and considering all of the study’s problems and limitations. Sadly, I have also found that many docs just don’t know much about research and are therefore unable to assess study results intelligently. Wish they were all as wise as you! October 28, 2012 at 09:59 | Report abuse | WS DrJohn You said “1 in 3 will have a osteoporosis related fracture in their lifetime.” Also, more than 1 in 3 women develops heart disease.
For the original version including any supplementary images or video, visit http://thechart.blogs.cnn.com/2012/10/24/can-hormone-therapy-help-protect-the-brain/